An unprecedented revolution in mobility is happening, and automated vehicles (AVs) are part of it. This report explores key considerations for the deployment of AVs in the Greater Toronto and Hamilton Area, and articulates unifying design principles to guide cross-sector collaboration toward a safe, equitable, efficient, and integrated mobility future. The report identifies nine key challenges, and proposes near-term actions and prototypes for each challenge, to accelerate the transition to a mobility system that works for all.